A novel 3D solution for large-scale ex-vivo platelet production, transfusion and drug research
Why use SilkFusion system
SilkFusion is a groundbreaking 3D silk-fibroin technology for ex-vivo large-scale production of blood platelets for human transfusion from human pluripotent stem cells (hPSCs). Its core technology combines genetically engineered human pluripotent stem cells differentiating into megakaryocytes and functionalized silk-fibroin platforms and bio-inks to release the platelets from the megakaryocytes.
3D technology
3D silk-fibroin technology for ex-vivo production of platelets for transfusions.
Personalized treatment
Immunologically-matched platelets to allow immunized patients. Enhanced coagulation.
Affordable
Production of platelets for clinical transfusions in humans at an affordable cost.
Fast, scalable and self-sufficient
Large-scale platelet production in real time and upon demand.
Accurate
High-fidelity reproducible printing of silk-based clinical instruments to improve disease diagnosis.
Biocompatible and safe
Pathogen-free material. Approved by EMA/FDA. Not thrombogenic.
The problem to solve
The limited supply of human platelets and the rapidly growing demand for medical research and clinical applications including studies of platelet-related disease mechanisms and platelet transfusions for patients, are manifest.
Due to the ageing population and ever more aggressive chemotherapies, platelet demand is increasing by 10% every year, while the supply of platelets is entirely dependent on allogenic donations. In Europe, the demand of platelets averages 5 units per 1,000 population per annum, i.e. 2.5 million units per year, costing over €375 million. Lastly, there is a clear need for reproducible solutions to assist patients with acute haemorrhage resulting from trauma, surgery and emergency treatment in conflict zones.